Research on the mechanism of Xiaoluo Bolus in treating malignant lymphoma based on network pharmacology
10.3760/cma.j.cn115398-20210126-00268
- VernacularTitle:基于网络药理学探讨消瘰丸治疗恶性淋巴瘤作用机制
- Author:
Fupeng ZHANG
1
;
Yongming ZHOU
Author Information
1. 上海中医药大学附属岳阳中西医结合医院血液内科，上海 200437
- Keywords:
Lymphoma;
Xiaoluo Bolus;
Network Pharmacology;
Molecular mechanisms of Pharmacological action (TCD)
- From:
International Journal of Traditional Chinese Medicine
2022;44(5):555-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the pharmacological mechanism of Xiaoluo Bolus in treating Malignant Lymphoma based on network pharmacology so as to provide references for the R&D of new drugs and clinical use of classic formulation.Methods:This paper collected the main chemical components of Scrophulariaceae, Fritillaria, Oyster and their targets through TCMSP Database and selected active ingredients according to ADME. The main lymphoma target genes were acquired by GeneCards, OMIN, TTD, DURGBANK database. The main targets of Xiaoluo Bolus treating lymphoma were screened by using BisoGenet function in Cytoscape and PPI network of Xiaoluo Bolus compounds-Malignant Lymphoma target was constructed. Metascape data platform was used to analyze signal pathways of Xiaoluo Bolus and construct the network of Xiaoluo Bolus compounds-Malignant Lymphoma target-signal pathway.Results:The core effective ingredients of Xiaoluo Bolus which could treat Malignant Lymphoma were harpagoside, Zhebeiresinol, pelargonidin and the targets were PRS27A, TP53, PPP2CA, which mainly takes effect on NF-κB、HIF-1 pathways. The main function of them is to act on the rDNA chromatin silencing and megakaryocyte differentiation.The common deubiquitination function in these two pathways indicated the main therapeutic target of Xiaoluo Bolus treating malignant lymphoma.Conclusion:This study initially revealed the multi-component, multi-target, and multi-collateral mechanism of Xiaoluo Bolus, in the treatment of malignant lymphoma which provids the scientific base for the development and utilization of Xiaoluo Bolus in clinical use.
