Clinical study of Chaihu Shugan Powder in the treatment of cancer-related depression
10.3760/cma.j.cn115398-20210114-00138
- VernacularTitle:柴胡疏肝散治疗肿瘤相关性抑郁肝郁脾虚证临床研究
- Author:
Haiyan DENG
1
;
Shengping WU
;
Xiaofang WU
;
Dan LIU
Author Information
1. 北京市中西医结合医院肿瘤科，北京 100013
- Keywords:
Chai Hu Shu Gan San;
Melancholia;
Cancer related depression
- From:
International Journal of Traditional Chinese Medicine
2022;44(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the clinical effect of Chaihu Shugan Powder in the treatment of liver qi and spleen deficiency syndrome on cancer related depression (CRD).Methods:A total of 63 patients with cancer related depression from our hospital during September 2018 to October 2019 were divided into observation group (42 cases) and control group (21 cases) according to the ratio of 2 :1. The observation group was applied with Chaihu Shugan Powder, while the control group was given placebo agent of Chaihu-Shugan with 2% Chaihu-Shugan Powder and 98% dextrin. Both groups were treated continuously for 42 days. We used HAMD24 and Traditional Chinese Medicine (TCM) Symptoms Scale to evaluate both before and after treatment. Results:The total efficiency about depression in the observation group was 71.4% (30/42) while the control group was 14.3% (3/21). The difference was statistically significant ( Z=-4.22, P<0.01). After treatment, The HAMD scales of the observation group was 18.67±3.55 while the control group was 24.71±3.74 ( P<0.05). The total effective rate of TCM syndrome in the observation group was 71.4% (30/42) and that in the control group was 14.3% (3/21). There was significant difference between the two groups ( Z=-4.00, P<0.01). TCM Syndrome Score of observation group was 55.33±17.59 while the control group was 62.04±10.72( t=-2.00, P<0.05). Conclusion:Chaihu Shugan Powder can effectively improve the anxiety and depression of CRD patients with syndrome of stagnation of liver qi and spleen deficiency.
