Research progress of Fusobacterium nucleatum and occurrence and development of colorectal cancer

VernacularTitle:具核梭杆菌与结直肠癌发生发展的研究进展
Author: Xiaokang HE ¹ ; Xian TU ; Fei YAO ; Qingming WU
Author Information

1. 武汉科技大学附属天佑医院消化内科，武汉　430064
Keywords: Fusobacterium nucleatum; Colorectal neoplasms; Prognosis
From: Journal of International Oncology 2022;49(2):121-124
CountryChina
Language:Chinese
Abstract: Colorectal cancer (CRC) is a common malignant tumor of the digestive tract, which seriously threatens human health. In recent years, many studies have found that Fusobacterium nucleatum (Fn) is positively related to the occurrence of CRC. In the process of CRC carcinogenesis, Fn can play an important role by inducing the expression of pro-inflammatory cytokines and triggering chronic inflammation, inhibiting the function of immune cells, inducing chemotherapy resistance, promoting the expressions of tumor genes and microRNAs and regulating glycolysis.