Research progress in genetic susceptibility genes and related pathogenic factors and treatment of neoplastic calcinosis
10.3760/cma.j.cn121382-20210618-00614
- VernacularTitle:肿瘤性钙盐沉着症遗传易感基因和相关致病因素分析及其治疗的研究进展
- Author:
Yanjun WANG
1
;
Guangrun LI
;
Guishi LI
;
Xiaoyang LIU
Author Information
1. 滨州医学院第二临床医学院，烟台 264003
- Keywords:
Tumoral calcinosis;
Genetic susceptibility genes;
Pathogenic factors
- From:
International Journal of Biomedical Engineering
2021;44(6):496-500,515
- CountryChina
- Language:Chinese
-
Abstract:
Tumor calcinosis(TC) has different clinical and biochemical patterns. The existence of chronic injury as well as calcium and phosphorus metabolism disorder has been gradually proved to be the important link in the occurrence of TC. In this paper, the related basic diseases with the pathophysiological mechanism of calcium and phosphorus metabolism disorder were reviewed, and the pathophysiological mechanism of phosphate metabolism disorder in various diseases was summarized.In addition, the phosphate homeostasis genes including GALNT-3, FGF-23 and α-KLOTHO were described. The relevant research results have showed that mutations in any of these three genes will lead to defects in the synthesis or action of FGF-23, which will increase the reabsorption of phosphate by renal tubules, resulting in hyperphosphatemia and severe ectopic calcification of soft tissue.At present, surgical resection is still the main treatment of TC. New technologies such as cinalcet peritoneal dialysis, ultrasound-guided aspiration of TC lesions and local injection of sodium thiosulfate (STS), as well as the successful application of lanthanum carbonate and other drugs, provide alternatives to TC treatment.In this paper, the research literatures on TC at home and abroad in recent years were introduced and the genetic susceptibility genes, related pathogenic factors and the latest treatment progress of TC were reviewed.
