Correlation between obstructive sleep apnea and triglyceride-glucose index in patients with ischemic stroke
10.3760/cma.j.issn.1673-4165.2022.03.005
- VernacularTitle:阻塞性睡眠呼吸暂停与缺血性卒中患者甘油三酯葡萄糖指数的相关性
- Author:
Xiang LI
1
;
Tao MOU
;
Yifei LI
;
Wusheng ZHU
;
Gelin XU
Author Information
1. 南京医科大学金陵临床医学院（东部战区总医院）神经内科，南京 210002
- Keywords:
Stroke;
Brain ischemia;
Sleep apnea, obstructive;
Insulin resistance;
Triglycerides;
Blood glucose
- From:
International Journal of Cerebrovascular Diseases
2022;30(3):184-189
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between obstructive sleep apnea (OSA) and triglyceride-glucose (TyG) indexin patients with ischemic stroke.Methods:Patients with ischemic stroke underwent sleep breathing monitoring in Nanjing Stroke Registry Program from August 2020 to August 2021 were retrospectively enrolled. According to apnea-hypopnea index (AHI), the patients were divided into no/mild OSA group (AHI≤15 events/h) and moderate to severe OSA group (AHI>15 events/h). The TyG index was calculated according to triglycerides and fasting blood glucose, and the patients were grouped by quartile. The relationship between moderate to severe OSA and TyG index was determined by ordinal multinomial logistic regression analysis. Pearson correlation analysis was used to evaluate the correlation between TyG index and AHI. Results:A total of 155 patients with ischemic stroke were enrolled in the study, including 66 patients in the no/mild OSA group, 89 in the moderate to severe OSA group; 39 in the Q1 group (TyG index ≤8.46), 39 in the Q2 group (TyG index 8.47-8.78), 39 in the Q3 group (TyG index 8.79-9.17), and 38 in the Q4 group (TyG index >9.17). Ordinal multinomial logistic regression analysis showed that after adjusting for potential confounding factors, higher fasting blood glucose (odds ratio 2.370, 95% confidence interval 1.745-3.222; P<0.001) and moderate to severe OSA (odds ratio 2.377, 95% confidence interval 1.217-4.646; P=0.011) had significant independent positive correlation with TyG index. Pearson correlation analysis showed that AHI was positively correlated with the TyG index in patients with ischemic stroke ( r=0.209, P=0.011). Conclusion:OSA is independently correlated with TyG index in patients with ischemic stroke.
