The sensitization of thymic stromal lymphopoietin to type 2 lymphocytes in the lung
10.3760/cma.j.issn.1673-4408.2022.03.008
- VernacularTitle:胸腺基质淋巴生成素对肺部2型淋巴细胞的致敏作用研究进展
- Author:
Dongni WANG
1
;
Yunxiao SHANG
Author Information
1. 中国医科大学附属盛京医院小儿呼吸内科，沈阳 110004
- Keywords:
Thymic stromal lymphopoietin;
Type 2 T helper cells;
Type 2 innate lymphocytes;
Type 2 cytokine;
Lung
- From:
International Journal of Pediatrics
2022;49(3):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Thymic stromal lymphopoietin(TSLP)can enhance the secretion of type 2 cytokines by type 2 T helper(Th2)cells and type 2 innate iymphocytes(ILC2s)in the lung through direct and indirect action.In terms of indirect effects, TSLP can promote the proliferation and expansion of naive CD4 + T cells by using dendritic cells, and promote the recruitment of Th2 cells to the initial inflammatory site.It can also use stromal mononuclear/macrophages cells to start the acute primary Th2-dependent immune response.In the aspect of direct effect, TSLP can activate ILC2s before the adaptive immune response is initiated, and also can use immature T cells, effector Th2 cells and memory Th2 cells to participate in the adaptive immune response.Therefore, TSLP plays an important role in allergic immune response of lung.
