Research progress of cystine/glutamate antiporter as drug targets
10.16438/j.0513-4870.2022-0542
- VernacularTitle:胱氨酸/谷氨酸反向转运体作为药物靶点的研究进展
- Author:
Nan JIANG
1
;
Li-da DU
2
;
De-wen KONG
3
;
Xiao-bin PANG
4
;
Guan-hua DU
1
Author Information
1. School of Pharmacy, Henan University, Kaifeng 475004, China; Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
2. Department of Surgery, University of Toronto, Toronto M5S1A8, Canada
3. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
4. School of Pharmacy, Henan University, Kaifeng 475004, China
- Publication Type:Research Article
- Keywords:
cystine/glutamate antiporter;
oxidative stress;
glutamate neurotoxicity;
ferroptosis;
rug target
- From:
Acta Pharmaceutica Sinica
2022;57(6):1621-1629
- CountryChina
- Language:Chinese
-
Abstract:
Cystine/glutamate antiporter [system Xc(-)] is a sodium independent amino acid transporter, which is a heterodimer composed of light chain subunit xCT and heavy chain subunit 4F2hc (CD98) through covalent disulfide bond. System Xc(-) typically mediates cystine uptake and glutamate output, helps to maintain the balance of glutamate, cystine and cysteine inside and outside the cell, regulates the level of glutamate inside and outside the membrane and the synthesis of intracellular glutathione, thus affecting oxidative stress and glutamate neurotoxicity. This review expounds the structure and function of system Xc(-), analyzes the role of the transporter in physiology and pathology, discusses the role and mechanism in different diseases, and discusses the specific research progress of system Xc(-) as a drug target. This review summarizes the research status of system Xc(-) and provides theoretical guidance for further research on system Xc(-) and drug discovery.
