Advances of quantitative systems pharmacology in antitumor drug research
10.16438/j.0513-4870.2022-0091
- VernacularTitle:定量系统药理学在抗肿瘤药物研究中的进展
- Author:
Di-hong YANG
1
;
Chen-yu WANG
2
;
Luo FANG
3
;
Zheng JIAO
2
Author Information
1. Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China; Cancer Hospital of The University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou 310005, China
2. Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
3. Cancer Hospital of The University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou 310005, China
- Publication Type:Research Article
- Keywords:
quantitative systems pharmacology;
antitumor drug;
mechanism;
osage regimen;
biomarker
- From:
Acta Pharmaceutica Sinica
2022;57(6):1726-1733
- CountryChina
- Language:Chinese
-
Abstract:
The high mortality of tumor is one of the most urgent problems to be solved. However, the current clinical trials provide limited quantitative descriptions on dynamic changes of drug efficacy, which restrict the selection of dosing regimens. Quantitative systems pharmacology (QSP) is a new approach for precise treatment of tumors. It quantifies the network relationship between drug action and diseases by integrating the tumor growth and molecules, cells in vivo, thereby predicting the efficacy, toxicity, and mechanism of antitumor drugs as well as identifying predictive biomarkers. In this review, we provide an overview of definition of QSP, current approaches and typical applications in research of antitumor drugs to enhance our understanding of QSP.
