A new nucleoside from the Oenothera biennis L.
- VernacularTitle:月见草中一个新的核苷类化合物
- Author:
Juan-juan LIU
1
;
Jing-ke ZHANG
1
;
Qin-qin ZHANG
1
;
Meng LI
1
;
Deng-hui ZHU
1
;
Jun-jun WEI
1
;
Xiao-ke ZHENG
1
;
Wei-sheng FENG
1
Author Information
- Publication Type:Research Article
- Keywords: italic>Oenothera biennis L.; chemical constituent; nucleoside; BEAS-2B cell; MTT
- From: Acta Pharmaceutica Sinica 2022;57(6):1840-1844
- CountryChina
- Language:Chinese
-
Abstract:
Seven nucleoside compounds were isolated from the
Oenothera biennis L. by various chromatographic techniques such as Diaion HP-20, silica gel, Sephadex LH-20, MCI and semi-preparative HPLC. Their structures were identified by analysis of physicochemical properties and spectral data, and determined as 9-(3′-carbonyl methyl)hydroxypurine (1 ), 1-(3′-carbonyl methyl)purine-6,8-dione (2 ),N -methyl-2-pyridone-5-carboxamide (3 ), uracil (4 ), uridine (5 ), thymidine (6 ) and 2′-Ο -methoxy luridine (7 ). Compound1 is a new nucleoside and compounds2 -7 were newly isolated from theOenothera biennis L.1 -2 can significantly increase the viability of BEAS-2B cells induced by TGF-β 1, showing potent anti-pulmonary fibrosis activity.
