Research progress of tumor microenvironmentally regulating organelle targeted drug delivery system
10.16438/j.0513-4870.2021-1353
- VernacularTitle:肿瘤微环境调节型细胞器靶向递药系统的研究进展
- Author:
Shi-yang WU
1
;
Shuang CHANG
1
;
Qing CHEN
2
;
Meng-hao SHI
1
;
Ming ZHAO
1
;
Hai-yang HU
1
;
Da-wei CHEN
1
Author Information
1. Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
2. Department of Pharmacology, Iowa University, Iowa City 50011, USA
- Publication Type:Research Article
- Keywords:
rug delivery system;
tumor microenvironment;
organelle;
targeting;
hydrogen-ion concentration;
reactive oxygen species;
immunogenicity;
immunosuppression
- From:
Acta Pharmaceutica Sinica
2022;57(6):1771-1780
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the use of the body's immune system for anti-tumor immunotherapy has received extensive attention. However, the immunosuppressive tumor microenvironment (TME) limits the effect of immunotherapy. Therefore, overcoming the limitations of TME and immunosuppressive cells plays an important role in tumor immunotherapy. Nano agents have great potential to reprogram the immunosuppressive microenvironment and provide an effective strategy for immunotherapy. With the continuous development of active targeting nano carrier technology and the deepening of the research on drug action sites, subcellular organ targeting nano carrier materials with more accurate active targeting function have also attracted more and more attention. This review will briefly introduce the relationship between subcellular organelles and tumor, summarize the design strategy and research progress of targeted nano drug delivery system based on the characteristics of acidity, reactive oxygen species (ROS) activity, immunogenicity, and TME of immunosuppressive cells, to provide reference for the construction of subcellular pathway targeted drug delivery system in tumor immunotherapy.
