B cells and tumor immune escape.
10.11817/j.issn.1672-7347.2022.210275
- Author:
Huiting LI
1
,
2
;
Guiyuan LI
1
;
Ping XU
3
;
Zheng LI
1
,
4
Author Information
1. Cancer Research Institute, Central South University, Changsha
2. lihuiting@csu.edu.cn.
3. Departments of Respiratory and Critical Care Medicine, Peking University Shenzhen Hospital, Shenzhen Guangdong 518036, China.
4. lizheng@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
B cells;
regulatory B cell;
tertiary lymphoid structure;
tumor immune escape
- MeSH:
B-Lymphocytes/pathology*;
Humans;
Immunotherapy;
Neoplasms/therapy*;
Tumor Escape;
Tumor Microenvironment
- From:
Journal of Central South University(Medical Sciences)
2022;47(3):358-363
- CountryChina
- Language:English
-
Abstract:
B lymphocyte is an important component of the human immune system and it has a role in the process of the body's specific immunity. In recent years, the research on B cells and tumor immune escape has rapidly progressed. Studies have shown that different types of B cells play different roles in tumor microenvironment through a variety of mechanisms. B cells in the tertiary lymphatic structure promote anti-tumor immunity, while regulatory B cells promote tumor immune escape. Antibody drugs targeting B cells are a promising direction for tumor immunotherapy.
