Polymorphisms of the Reg1alpha Gene and Early Onset Type 2 Diabetes in the Korean Population.
10.4093/kdj.2010.34.4.229
- Author:
Bo Kyung KOO
1
;
Young Min CHO
;
Kuchan KIMM
;
Jong Young LEE
;
Bermseok OH
;
Byung Lae PARK
;
Hyun Sub CHEONG
;
Hyoung Doo SHIN
;
Kyung Soo KO
;
Sang Gyu PARK
;
Hong Kyu LEE
;
Kyong Soo PARK
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. kspark@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus, type 2;
Polymorphism;
Reg1alpha gene
- MeSH:
Animals;
Diabetes Mellitus, Type 2;
DNA;
Haplotypes;
Humans;
Mice
- From:Korean Diabetes Journal
2010;34(4):229-236
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The Reg gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As human Reg1alpha is homologous with murine Reg1, we investigated whether common variants in Reg1alpha are associated with type 2 diabetes in the Korean population. METHODS: We sequenced the Reg1alpha gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel], and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects. RESULTS: No polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype H1, composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877], P = 0.009). CONCLUSION: Polymorphisms in the Reg1alpha were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population.
