Correlation and Influencing Factors of SUVmax and Ki-67 in Non-Hodgkin Lymphoma.
10.19746/j.cnki.issn.1009-2137.2022.01.022
- Author:
Juan LI
1
;
Ming ZHAO
2
;
Ling YUAN
3
;
Yang LIU
3
;
Ning MA
3
Author Information
1. Department of Medical Imaging, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
2. Department of Positron Emission Computed Tomography Center, Shanxi Provincial Cancer Hospital, Taiyuan 030013, Shanxi Province, China,E-mail: zhaoming19701025@yahoo.com.
3. Department of Positron Emission Computed Tomography Center, Shanxi Provincial Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
- Publication Type:Journal Article
- Keywords:
Ki-67;
non-Hodgkin lymphoma;
positron emission tomography/computed tomography
- MeSH:
Fluorodeoxyglucose F18;
Humans;
Ki-67 Antigen;
Lymphoma, Non-Hodgkin;
Positron Emission Tomography Computed Tomography;
Positron-Emission Tomography;
Retrospective Studies
- From:
Journal of Experimental Hematology
2022;30(1):136-140
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the influencing factors of maximum standard uptake value (SUVmax) of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and nuclear antigen Ki-67 in non-Hodgkin lymphoma (NHL) and their correlation.
METHODS:The relationship between SUVmax, Ki-67 and gender, age, maximum lesion diameter, extranodal involvement, superficial and deep lymph node involvement, malignancy, B symptoms, clinical stage, lactate dehydrogenase (LDH) and international prognostic index (IPI) scores and their correlation were reviewed.
RESULTS:Among 185 NHL patients, 99 cases were aggressive B-cell NHL, 43 cases were indolent B-cell NHL, and 43 cases were T-cell NHL, respectively. Obviously, the SUVmax and Ki-67 of aggressive B-cell NHL were higher than those of indolent B-cell NHL and T-cell NHL (P<0.05), while indolent B-cell NHL were lower than those of T-cell NHL (P<0.05). SUVmax and Ki-67 were closely related to maximum lesion diameter, extranodal involvement, malignancy, LDH, and IPI scores (P<0.05). SUVmax was positively correlated with Ki-67 expression (r=0.615). According to the analysis of receiver operating characteristic (ROC), the results showed that the SUVmax and Ki-67 could reflect the aggressiveness of NHL accurately, with an AUC of 0.871 and 0.968.
CONCLUSION:SUVmax and Ki-67 are not affected by age, sex, B symptoms, clinical stage and so on, and are relatively objective quantitative parameters. SUVmax is positively correlated with Ki-67 expression in NHL. SUVmax and Ki-67 have certain value in clinical diagnosis of malignant degree of NHL.
