Cerebrospinal Fluid β2-Microglobulin for Prognostic Evaluation of Patients with Central Nervous System Infiltration in Acute Lymphoblastic Leukemia.
10.19746/j.cnki.issn.1009-2137.2022.01.018
- Author:
Meng-Li YAO
1
;
Ting-Mei CHEN
1
;
Pu LI
2
Author Information
1. Key Laboratory of Diagnostic Medicine of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China.
2. Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China,E-mail: lipu@hospital.cqmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
acute lymphocytic leukemia;
central nervous system invasion;
cerebrospinal fluid β2-microglobulin;
prognostic evaluation
- MeSH:
Central Nervous System;
Cerebrospinal Fluid;
Humans;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Prognosis;
Remission Induction;
beta 2-Microglobulin
- From:
Journal of Experimental Hematology
2022;30(1):113-118
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the prognostic value of serum and cerebrospinal fluid β2-microglobulin (β2-MG) in acute lymphoblastic leukemia (ALL) with central nervous system invasion after chemotherapy.
METHODS:40 patients with leukemia who had been confirmed to have central nervous system infiltration were selected for treatment at the Second Affiliated Hospital of Chongqing Medical University from January 2015 to May 2017, and the serum levels of β2-MG and CSF-β2MG were dynamically monitored and performed statistical analysis.
RESULTS:After chemotherapy, the changes in serum β2-MG were not statistically significant (P>0.05); the absolute level of CSF-β2MG and the percentage of relative baseline changes were statistically different in different clinical outcome groups(P<0.05), and the decreasing CSF-β2MG levels suggest a better prognosis, with cut-off values of 1.505 and -25%, respectively.
CONCLUSION:The best cut-off point may be a predictor of complete remission; the reduction of the absolute and relative levels of CSF-β2MG can suggest a good prognosis for patients.
