A new norsesquiterpenoid from Schisandra chinensis.
10.19540/j.cnki.cjcmm.20211203.201
- Author:
Yong-Cheng YANG
1
;
Jiang-Chun WEI
1
;
Lu-Qi LIU
1
;
San-Peng FAN
1
;
Min CHEN
2
;
An-Hua WANG
1
;
Jing-Ming JIA
1
Author Information
1. School of Chinese Materia Medica, Shenyang Pharmaceutical University Shenyang 110016, China.
2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Shenyang 110033, China.
- Publication Type:Journal Article
- Keywords:
Schisandra chinensis;
chemical composition;
identification;
norsesquiterpenoid
- MeSH:
Chromatography, High Pressure Liquid;
Magnetic Resonance Spectroscopy;
Mass Spectrometry;
Plant Leaves/chemistry*;
Schisandra
- From:
China Journal of Chinese Materia Medica
2022;47(6):1582-1586
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the chemical components from the leaves and stems of Schisandra chinensis. Three norsesquiterpenoids were isolated from S. chinensis by various column chromatographies(silica gel, Sephadex LH-20, and MCI), reversed-phase medium-pressure preparative, and semi-preparative high-performance liquid chromatography(HPLC). Their structures were identified based on physicochemical properties, mass spectrometry(MS), nuclear magnetic resonance(NMR), ultraviolet(UV), and electro-nic circular dichroism(ECD) as(3R,4R,5R,6S,7E)-3,4,5,6-tetrahydroxy-7-megastigmen-9-one(1),(3S,5R,6R,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(2), and(3S,4R,9R)-3,4,9-trihydroxymegastigman-5-ene(3). Compound 1 was a new compound, and its absolute configuration was determined by ECD. Compounds 2 and 3 were isolated from the Schisandra plant for the first time.
