Research Progress of Fatty Acid Desaturase 2 Gene in Glycolipid Metabolism.
10.3881/j.issn.1000-503X.14235
- Author:
Guo-Jie WANG
1
;
Ye TIAN
1
;
Hui-Ying ZHANG
1
Author Information
1. Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital,Tianjin 300052,China.
- Publication Type:Review
- Keywords:
delta-6 desaturase;
fatty acid desaturase 2 gene;
glucose metabolism;
lipid metabolism
- MeSH:
Fatty Acid Desaturases/metabolism*;
Glycolipids/metabolism*;
Humans;
Polymorphism, Single Nucleotide
- From:
Acta Academiae Medicinae Sinicae
2022;44(1):158-163
- CountryChina
- Language:Chinese
-
Abstract:
The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and α-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism.
