- Author:
	        		
		        		
		        		
			        		Alejandro Figar GUTIÉRREZ
			        		
			        		
			        		
			        			1
			        			
			        		
			        		
			        		
			        		
			        		;
		        		
		        		
		        		
			        		Francisco C. BONOFIGLIO
			        		
			        		;
		        		
		        		
		        		
			        		John George KARIPPACHERIL
			        		
			        		;
		        		
		        		
		        		
			        		Francisco O. REDELICO
			        		
			        		;
		        		
		        		
		        		
			        		Maria de Los Angeles ITURRALDE
			        		
			        		
		        		
		        		
		        		
			        		
			        		Author Information
			        		
 - Publication Type:Case Report
 - From:Korean Journal of Anesthesiology 2022;75(1):86-96
 - CountryRepublic of Korea
 - Language:English
 - 
		        	Abstract:
			       	
			       		
				        
				        	 Background:To detect an early increase in the inflammatory response might prove to be vital for mitigating the deleterious effects of the disease over time.Case: A 52-year-old obese man with moderate asthma and hypertension, who developed COVID-19 and had moderate symptoms, used a wearable device to record heart rate variability (HRV) during his illness. He had low parasympathetic tone, which decreased daily until it reached almost 2 standard deviations (SD) below normal values at the end of the second week. His sympathetic tone increased from > 3 SD to > 5 SD. 
				        	
Conclusions:These findings suggest an altered modulation of the sympathetic and parasympathetic nervous systems in COVID-19, such that the sympathetic tone is augmented and the parasympathetic tone is reduced. Population norms of COVID-19 infections should be further studied over the short-term and using 24 h HRV measurements. 
            
