Next generation sequencing-based salivary biomarkers in oral squamous cell carcinoma
10.5125/jkaoms.2022.48.1.3
- Author:
Buyanbileg SODNOM-ISH
1
;
Mi Young EO
;
Hoon MYOUNG
;
Jong Ho LEE
;
Soung Min KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea
- Publication Type:INVITED REVIEW ARTICLE
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2022;48(1):3-12
- CountryRepublic of Korea
- Language:English
-
Abstract:
Selection of potential disease-specific biomarkers from saliva or epithelial tissues through next generation sequencing (NGS)-based protein studies has recently become possible. The early diagnosis of oral squamous cell carcinoma (OSCC) has been difficult, if not impossible, until now due to the lack of an effective OSCC biomarker and efficient molecular validation method. The aim of this study was to summarize the advances in the application of NGS in cancer research and to propose potential proteomic and genomic saliva biomarkers for NGS-based study in OSCC screening and diagnosis programs. We have reviewed four categories including definitions and use of NGS, salivary biomarkers and OSCC, current biomarkers using the NGSbased technique, and potential salivary biomarker candidates in OSCC using NGS
