A Retrospective Population-Based Survival Study of Idiopathic Pulmonary Arterial Hypertension in Korea
- Author:
Shin Yi JANG
1
;
Eun Kyoung KIM
;
June HUH
;
Jinyoung SONG
;
I-Seok KANG
;
Seung Woo PARK
;
Duk-Kyung KIM
;
Sung-A CHANG
Author Information
- Publication Type:Original Article
- From:Journal of Korean Medical Science 2022;37(10):e80-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Few studies used nationwide data to assess the survival rates (SRs) and death risk for idiopathic pulmonary arterial hypertension (IPAH; ICD-10 I27.0) in Korea.
Methods:IPAH data (N = 9,017; female:male = 6:4) were collected from the National Health Insurance Service in Korea, from 2006 through 2017. The data consisted of primary diagnoses related to IPAH. The Kaplan–Meier method and Cox proportional-hazards analyses were carried out.
Results:The mean age was 62.3 (± 19.4) years, 64.2 (± 18.9) years in female and 59.4 (± 19.8) years in male (P < 0.001). The one-, three-, five- and 10-year SRs for IPAH were 89.0%, 79.8%, 72.3% and 57.0%, respectively. The adjusted hazard ratio (HR) of IPAH was 1.81 (95% confidence interval [CI], 1.26–2.59) in 60–69 age group, 3.42 (95% CI, 2.40–4.87) in 70–79, and 7.73 (95% CI, 5.43–11.0) in 80s. Other risk factors were male, low-income status, diabetes, myocardial infarction, atrial fibrillation, ischemic stroke, hemorrhagic stroke, and malignant neoplasm.
Conclusion:The 10-year SR of IPAH was 57% in Korea. The HR for IPAH was significantly high in patients with older age and other risk factors.
