Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis
10.4174/astr.2022.102.4.193
- Author:
Suk Kyun HONG
1
;
Kwang-Woong LEE
;
Sola LEE
;
Su young HONG
;
Sanggyun SUH
;
Eui Soo HAN
;
YoungRok CHOI
;
Nam-Joon YI
;
Kyung-Suk SUH
Author Information
1. Department of Surgery, Seoul National University College of Medicine, Seoul, Korea
- Publication Type:ORIGINAL ARTICLE
- From:Annals of Surgical Treatment and Research
2022;102(4):193-204
- CountryRepublic of Korea
- Language:English
-
Abstract:
Purpose:The aim of this study was to compare surgical outcomes after liver resection for hepatocellular carcinoma (HCC) according to tumor size using a large, nationwide cancer registry-based cohort and propensity score matching.
Methods:From 2008 to 2015, a total of 12,139 patients were diagnosed with liver cancer and registered in the Korean Primary Liver Cancer Registry. Patients without distant metastasis who underwent hepatectomy as a primary treatment were selected. We performed 1:1 propensity score matching between the small (<5 cm), large (≥5 cm and <10 cm), and huge (≥10 cm) groups.
Results:Overall, 265 patients in the small and large groups were compared, and 64 patients each in the large and huge groups were compared. The overall and progression-free survival rates were significantly lower in the large group than in the small group (P < 0.001 and P < 0.001, respectively). Overall survival tended to be poorer in the huge group than in the large group (P = 0.051). The progression-free survival rate was significantly lower in the huge group than in the large group (P = 0.002).
Conclusion:Although primary liver resection can be considered even in patients with huge HCC, greater caution with careful screening for recurrence is needed.
