Role and mechanism of interleukin-35 in hepatitis B virus-related diseases
10.3969/j.issn.1001-5256.2022.05.036
- VernacularTitle:IL-35在HBV感染所致疾病中的调控作用和相关机制
- Author:
Xiaofei YANG
1
;
Jianqi LIAN
1
;
Ye ZHANG
1
Author Information
1. Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University & The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, China
- Publication Type:Reviews
- Keywords:
Hepatitis B virus;
Interleukins;
Immunomodulation
- From:
Journal of Clinical Hepatology
2022;38(5):1148-1151
- CountryChina
- Language:Chinese
-
Abstract:
Interleukin-35 (IL-35) is an immunosuppressive cytokine mainly secreted by regulatory T cells and regulatory B cells and is involved in the pathogenesis of infectious diseases, tumors, and autoimmune diseases. This article summarizes the immunoregulatory role and mechanism of IL-35 in hepatitis B, liver cirrhosis, liver failure, and hepatocellular carcinoma caused by hepatitis B virus (HBV) infection. The analysis shows that IL-35 is a "double-edged sword" in HBV-related diseases, and it can not only promote the chronicity of infection and the progression of hepatocellular carcinoma, but also alleviate liver inflammation and inhibit liver fibrosis.
