Research progress on Fe-based metal-organic frameworks in antitumor drug delivery
10.16438/j.0513-4870.2021-1263
- VernacularTitle:Fe基金属-有机框架在抗肿瘤药物递送方面的研究进展
- Author:
Hong GUO
1
;
Xia LI
1
;
Ding QU
1
;
Yan CHEN
1
Author Information
1. Affiliated Hospital of Intergrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China; Multi-component of Traditional Chinese Medicine and Microecology Research Center, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China
- Publication Type:Research Article
- Keywords:
Fe-based metal-organic framework;
antitumor;
rug delivery;
nano;
targeting
- From:
Acta Pharmaceutica Sinica
2022;57(5):1252-1262
- CountryChina
- Language:Chinese
-
Abstract:
Fe-based metal-organic frameworks (MOFs) are a class of polymer crystals formed by the combination of Fe ions or Fe clusters with organic ligands through coordination bonds. At present, Fe-based MOFs can be mainly prepared by solvothermal synthesis, ultrasonic synthesis, microwave synthesis, and dry-gel conversion, etc. Fe-based MOFs have the characteristics of strong drug loading capacity of inorganic nano-carrier and high safety of organic nano-carrier, and have good tumor targeting and the capacity of inducting tumor's ferroptosis, which have high potential in the delivery of antitumor drugs. Recently, Fe-based MOFs have also been developed with various functions such as imaging, magnetic hyperthermia, photothermal therapy, photodynamic therapy, and intelligent response, which can facilitate diagnosis and monitor drug distribution while delivering antitumor drugs, and can produce synergistic antitumor effects combined with thermotherapy and phototherapy, and can also control the precise release of drugs. Reviewing the advances in the synthesis methods, characteristics as well as functions and types of Fe-based MOFs can provide a basis for the further applications of Fe-based MOFs in antitumor drug delivery.
