Based on clinical application research progress of thermosensitive gel in different drug delivery sites
10.16438/j.0513-4870.2021-1209
- VernacularTitle:基于临床需求的温敏凝胶在不同给药部位的应用研究进展
- Author:
Ran-ran FAN
1
;
Yuan-bing LIU
2
;
Ting ZHANG
3
;
Zeng-ming WANG
4
;
Hui ZHANG
4
;
Jian-chun LI
5
;
Ai-ping ZHENG
4
Author Information
1. School of Pharmacy, Bengbu Medical College, Bengbu 233030, China; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
2. Unit 73101 of Chinese PLA, Xuzhou 221000, China
3. Zhengzhou University, Zhengzhou 450000, China
4. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
5. School of Pharmacy, Bengbu Medical College, Bengbu 233030, China
- Publication Type:Research Article
- Keywords:
thermosensitive gel;
administration site;
local administration;
thermosensitive material;
clinical need
- From:
Acta Pharmaceutica Sinica
2022;57(5):1235-1244
- CountryChina
- Language:Chinese
-
Abstract:
The advantages of local administration are as follow: release drugs directly at the lesion, increase the drug concentration in lesion location and reduce the side effects of systemic administration. Thermosensitive gel is one of typical local administration agents. It exhibits the different physical characteristics with the change of temperature. It is sol-gel at low temperature or storage temperature, while when the temperature rises to the transition temperature or near the body temperature, it is semisolid gel with a certain viscoelasticity, and can recover rapidly. It can enhance the local adhesion, which prolongs the local retention time of drugs. As a result, thermosensitive gel can control and display the release of drugs, which can significantly improve the bioavailability of drugs. This review summarizes the characteristics of thermosensitive gel, thermosensitive materials, and its application in different parts: nasal cavity, eye, vagina, periodontal, skin, tumor and joint cavity, based on clinical needs.
