Association between mitochondrial dysfunction and hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.06.045
- VernacularTitle:线粒体功能障碍与肝细胞癌的关系
- Author:
Xiaoqiang GAO
1
;
Shi ZUO
2
;
Xiaodong JIA
3
;
Yinying LU
3
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China;Comprehensive Liver Cancer Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
2. Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China
3. Comprehensive Liver Cancer Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
- Publication Type:Reviews
- Keywords:
Mitochondrion;
Carcinoma, Hepatocellular;
Therapeutics
- From:
Journal of Clinical Hepatology
2022;38(6):1436-1439
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is a type of tumor with a high incidence rate, a low rate of early diagnosis, and poor prognosis, and its development and progression involve many factors. As an important organelle in cells, mitochondria is the "energy factory" of cells and is one of the main sites for the production of reactive oxygen species in vivo, and it also participates in the regulation of cell apoptosis. There are varying degrees of changes in mitochondrial membrane, oxidation respiratory chain, mitochondrial dynamics, mitochondrial DNA, and mitochondrial calcium homeostasis during the development and progression of HCC, and such changes may affect the progression of HCC. This article systematically elaborates on the association between mitochondria and HCC, so as to provide a new direction for the diagnosis and treatment of HCC.
