Association of signal transducer and activator of transcription 3 and signal transducer and activator of transcription 5 with regulatory T cell/T helper 17 cell balance in chronic hepatitis B
10.3969/j.issn.1001-5256.2022.06.036
- VernacularTitle:慢性乙型肝炎信号转导及转录激活因子3、5与Treg/Th17平衡的关系
- Author:
Minyue LI
1
;
Hongju YANG
1
;
Jing LI
2
;
Rui SONG
1
;
Jing YOU
1
Author Information
1. NHC Key Laboratory of Drug Addiction Medicine, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. School of Public Health, Kunming Medical University, Kunming 650500, China
- Publication Type:Reviews
- Keywords:
Hepatitis B, Chronic;
STAT3 Transcription Factor;
STAT5 Transcription Factor;
T-Lymphocytes, Regulatory;
Th17 Cells
- From:
Journal of Clinical Hepatology
2022;38(6):1393-1397
- CountryChina
- Language:Chinese
-
Abstract:
The immune mechanism of chronic hepatitis B (CHB) persistent infection is closely associated with T cells, and the development of T cells requires the coordination of a variety of cytokines. The proteins of the signal transducer and activator of transcription (STAT) family are mainly involved in the signal transduction of cytokines, and STAT5a/b and STAT3 play an important role in the differentiation and development of regulatory T cells (Treg) and T helper 17 cells (Th17). This article analyzes the association of STAT3 and STAT5 with Treg/Th17 balance in CHB and investigates the chronicity of hepatitis B virus infection and the regulatory mechanism of liver inflammation.
