The role and mechanism of miRNA in exosomes of bone marrow mesenchymal stem cells in retinal neovascularization
10.3980/j.issn.1672-5123.2022.6.10
- VernacularTitle:骨髓间充质干细胞外泌体中miRNA在视网膜新生血管形成中的作用及机制
- Author:
Lu Zhang
1
Author Information
1. Department of Ophthalmology, Xijing Hospital, Fourth Military Medical of University, Xi'an 710032, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
bone marrow mesenchymal stem cells;
exosomes;
miRNA;
retinal neovascularization
- From:
International Eye Science
2022;22(6):936-940
- CountryChina
- Language:Chinese
-
Abstract:
Retinal vascular diseases such as retinopathy of prematurity, diabetic retinopathy, and retinal vein occlusion, and other retinal vascular diseases, with abnormal proliferation of retinal neovascularization as the main pathological manifestation. Exosomes derived from bone marrow mesenchymal stem cells transmit biologically active molecules through paracrine action to mediate the exchange of materials and information between cells. Among them, miRNA and other contents play key roles in transmitting information to regulate the proliferation of endothelial cells, the formation of the lumen, and new blood vessels in an ischemic and hypoxic environment. And it can cross the blood-retinal barrier without causing immune and inflammatory reactions and has great potential in the treatment of ophthalmic diseases. This article summarizes the role and possible mechanism of miRNA in bone marrow mesenchymal stem cell-derived exosomes in retinal neovascularization, with a view to broadening new ideas for the application of exosomes in the diagnosis and treatment of ophthalmic diseases.
- Full text:202206010.pdf
