Meta-analysis of the effectiveness and safety of parecoxib sodium for gynecological surgery and postoperative analgesia
- VernacularTitle:帕瑞昔布钠用于妇科手术及术后镇痛有效性和安全性的Meta分析
- Author:
Xin ZHANG
1
;
Linlin DENG
2
;
Huixin ZHAO
3
;
Chaojia ZHANG
4
;
Guoting XU
5
Author Information
1. Dept. of Rehabilitation Medicine，Nanyang Medical College，Henan Nanyang 473000，China
2. Teaching and Research Section of Obstetrics and Gynecology，Nanyang Medical College，Henan Nanyang 473000，China
3. Dept. of Obstetrics and Gynecology，Nanyang Hospital of TCM，Henan Nanyang 473000，China
4. Dept. of Nephrology，the First Affiliated Hospital of Nanyang Medical College，Henan Nanyang 473000，China
5. Dept. of Anesthesiology，the First Affiliated Hospital of Nanyang Medical College，Henan Nanyang 473000，China
- Publication Type:Journal Article
- Keywords:
parecoxib sodium;
gynecological surgery;
postoperative analgesia;
effectiveness;
safety;
Meta-analysis
- From:
China Pharmacy
2022;33(10):1258-1268
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically evaluate the effectiveness and s afety of parecoxib sodium for gynecological surgery postoperative analgesia ，and to provide evidence-based reference for clinical drug use. METHODS Retrieved from PubMed ， Embase，the Cochrane Library ，CNKI，VIP，Wanfang data and SinoMed during the inception to Feb. 16th，2021，randomized controlled trials （RCT） about parecoxib sodium （trial group ） versus 0.9％ sodium chloride injection （control group ） for gynecological surgery and postoperative analgesia were collected. After screening literatures ，extracting data and evaluating the quality of literatures with modified Jadad scale ，Meta-analysis，sensitivity analysis and publication bias analysis were performed by using RevMan 5.3 software. RESULTS A total of 14 RCT were included ，involving 1 120 patients. The results of Meta-analysis showed that visual analogue scale （VAS）score at 4 h after operation [MD ＝－1.65，95％CI（－2.48，－0.82），P＝0.000 1]，VAS score at 6 h after operation [MD ＝－1.03，95％CI（－1.60，－0.45），P＝0.000 5]，VAS score at 12 h after operation [MD ＝－0.98， 95％CI（－1.38， －0.59），P＜0.000 01]，the proportion of postoperative analgesia requirements [OR ＝0.14，95％CI（0.04， 0.50），P＝0.003] and the dosage of morphine [MD ＝ －17.75， com 95％CI（－20.93，－14.56），P＜0.000 01] in trial group were significantly lower than control group. There was no statistical significance in the incidence of nausea between 2 groups [OR＝ 0.68，95％CI（0.43，1.08），P＝0.10]. The results of sensitivity analysis showed that the above results were basically stable. The results of publication bias analysis showed that there was little possibility of publication bias in this study. CONCLUSIONS Parecoxib sodium is effective and safe for gynecological surgery and posto perative analgesia.
