Long-term protective effects of the nicotiflorin on ischemic stroke rats
10.12206/j.issn.1006-0111.202201080
- VernacularTitle:菸花苷对缺血性脑卒中大鼠的长期保护作用
- Author:
Xiaodong YAN
1
;
Yeqing WANG
1
;
Bingfeng LI
1
;
Meili GUO
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
nicotiflorin;
ischemic stroke;
neuroprotection;
pathology
- From:
Journal of Pharmaceutical Practice
2022;40(3):226-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the long-term protective effects of the nicotiflorin on ischemic stroke rats. Methods Ischemic stroke model in rats was established for this study. The effects of nicotiflorin on long-term survival rate, nervous system function, body weight and brain neurons in rats were observed. Results The nicotiflorin had significantly improved the long-term survival rate of cerebral ischemia rats, which also promoted weight gain, alleviated pathological damage of brain tissue, maintained morphology of brain neurons and function of nervous system. Conclusion The nicotiflorin has obvious long-term protective effect on ischemic stroke rats and the mechanism may be related to the protection of the structure and function of brain neurons.
