Progress in the study of polymyxin resistance and its mechanism
10.19428/j.cnki.sjpm.2022.20789
- VernacularTitle:多黏菌素耐药及其机制的研究进展
- Author:
Jia’an CAI
1
;
Lufang JIANG
2
;
Qingwu JIANG
2
Author Information
1. School of Basic Medical Sciences， Fudan University， Shanghai 200032， China
2. School of Public Health， Fudan University， Shanghai 200032， China
- Publication Type:Journal Article
- Keywords:
polymyxin;
drug resistance;
mechanism of polymyxin resistance;
transmission mode of polymyxin resistance;
plasmid-mediated polymyxin resistance
- From:
Shanghai Journal of Preventive Medicine
2022;34(3):283-287
- CountryChina
- Language:Chinese
-
Abstract:
Drug-resistant bacteria have become a serious threat to human health. Polymyxin has shown strong bactericidal activity to some Gram-negative and Gram-positive bacteria that are resistant to antibiotics， and has become a last-resort treatment option against a variety of multi-drug resistant bacteria. However， due to the abuse of polymyxin in animal breeding， the drug resistance rate of polymyxin in human population has significantly increased. In order to further understand the mechanism of polymyxin resistance， and to take measures to reduce the incidence of polymyxin resistance in the population， this paper reviewed the progress in research of the antibacterial mechanism of polymyxin， the prevalence of polymyxin resistance in the population， the mechanism of polymyxin resistance， and its transmission mode.
