Role of the ES-62 protein derived from Acanthocheilonema viteae in regulation of immune dysregulation diseases: a review
10.16250/j.32.1374.2021141
- VernacularTitle:魏氏棘唇线虫衍生抗原ES-62调节免疫失调性疾病 研究进展
- Author:
Qi HU
1
;
Jing-yu XING
1
;
Pei WU
1
;
Ting-ting HUANG
1
;
Xiao-di YANG
2
Author Information
1. Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, China
2. Anhui Provincial Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, China; Department of Microbiology and Parasitology, Bengbu Medical College, Bengbu, Anhui 233030, China
- Publication Type:Journal Article
- Keywords:
Acanthocheilonema viteae;
Excretory-secretory product;
ES-62;
Immune dysregulation diseases
- From:
Chinese Journal of Schistosomiasis Control
2022;34(2):204-211
- CountryChina
- Language:Chinese
-
Abstract:
ES-62 is a phosphorylcholine-containing, 62 kDa glycoprotein derived from the excretory-secretory product of Acanthocheilonema viteae, which is effective for the prevention and treatment of immune dysregulation diseases through triggering activation of immune cells, such as dendritic cells, mononuclear macrophages and regulatory B cells and mediating immune responses. Recently, the role of the ES-62 protein in the management of allergic, autoimmune and metabolic diseases has been paid much attention. This review summarizes the regulatory role of the ES-62 protein in immune dysregulation diseases and the underlying mechanisms, so as to provide insights into future experimental studies.
