Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease
10.3969/j.issn.1006-9771.2018.07.001
- VernacularTitle:儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性
- Author:
Huizi MA
1
;
Lingyan MA
1
;
Tao FENG
1
,
2
,
3
Author Information
1. Center for Neurodegenerative Disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2. China National Clinical Research Center for Neurological Disease, Beijing 100050, China;
3. Parkinson's Disease Center, Beijing Institute for Brain Disorder, Capital Medical University, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease, depression, catechol-O-methyltransferase, Val158Met, polymorphism
- From:
Chinese Journal of Rehabilitation Theory and Practice
2018;24(7):753-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase (COMT) gene Val158Met site and depression in Parkinson's disease. Methods From June, 2016 to December, 2017, a cohort of 268 Chinese patients with Parkinson's disease and 252 age- and gender-matched healthy control subjects were recruited. The patients were divided into depression group (n=116) and non-depression group (n=152) according to Hamilton Depression Scale score. Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results No difference was identified in Val158Met polymorphism of genotype (χ2=0.78, P>0.05) and allele (χ2=0.25, P>0.05) among the depression group, the non-depression group and the control group. Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.
