Research progress of ferroptosis in cardiovascular diseases
- VernacularTitle:铁死亡在心血管疾病中的研究进展
- Author:
Xiaodi WANG
1
;
Xin CHEN
1
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, P. R. China
- Publication Type:Journal Article
- Keywords:
Ferroptosis;
iron storage;
lipid peroxidation;
cardiovascular diseases
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(04):497-501
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is a leading cause of death in Chinese population. It is of great significance to further explore the pathogenesis of cardiovascular diseases. Ferroptosis is a recently discovered iron-dependent and non-apoptotic form of regulated cell death, which exerts a regulatory role in a variety of biological events. Some studies have shown that ferroptosis plays an important role in the development of cardiovascular diseases. According to newly scientific reports, we summarized the mechanism and regulation in ferroptosis, and reviewed the results of ferroptosis in common cardiovascular diseases such as cardiac ischemia-reperfusion/myocardial infarction, cardiomyopathy, cardiac hypertrophy, atherosclerosis and abdominal aortic aneurysm.
