Study on chemical constituents of sponge-associated Aspergillus terreus
10.12206/j.issn.1006-0111.202107019
- VernacularTitle:海绵共附生土曲霉的化学成分研究
- Author:
Xi YU
1
;
Yuting WANG
1
;
Houwen LIN
2
;
Yating SUN
1
Author Information
1. School of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
2. Department of Pharmacy, Renji Hospital Affiliated to Medical College, Shanghai Jiaotong University, Shanghai 200127, China.
- Keywords:
Aspergillus terreus;
chemical constituent;
α-glucosidase inhibitory activity.
- From:
Journal of Pharmaceutical Practice
2022;40(2):120-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the chemical constituents of Aspergillus terreus from sponge epiphytic fungal. Methods Sephadex LH-20 column chromatography, silica gel column chromatography and high performance liquid chroma-tography were used to separate and purify the compounds. The structures of compounds were identified by spectroscopic data. The α-glucosidase inhibitory activity and antioxidant activity of the compounds were tested by PNPG and DPPH methods, respectively. Results Eight compounds were isolated from Aspergillus terreus and identified as methyl-3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate (1), terrelumamide A (2), emeheterone (3), (8R,9S)-dihydroisoflavipucine (4), (8S,9S)-dihydroisoflavipucine (5), cyclo(S-Pro-S-Phe) (6), brevianamide F (7), terrein (8). Compound 3 showed strong inhibitory activity against α-glucosidase and the IC50 value was 14.28 μmol/L. Conclusion Compounds 3, 4, 5, and 7 were obtained from Aspergillus terreus for the first time.
