Research progress of the effect of flavonoids on cardiovascular and cerebrovascular ischemic diseases
10.12206/j.issn.1006-0111.202111059
- VernacularTitle:黄酮类化合物抗心脑血管缺血性疾病作用的研究进展
- Author:
Xiaodong YAN
1
;
Meili GUO
1
Author Information
1. Department of Pharmacognosy, School of Pharmacy , Naval Medical University, Shanghai 200433, China.
- Keywords:
flavonoids;
ischemic heart disease;
ischemic stroke;
protective effect;
mechanism of action
- From:
Journal of Pharmaceutical Practice
2022;40(2):97-102
- CountryChina
- Language:Chinese
-
Abstract:
Flavonoids are secondary metabolites that widely existing in traditional Chinese medicine. They have many biological activities and pharmacological effects. In recent years, studies have found that flavonoids can play an effective protective role in the treatments of ischemic stroke and ischemic heart disease through various ways. The mechanisms of their protective effects have been systematically explained in detail. For example, flavonoids can affect pathophysiological mechanisms such as antioxidant, inhibition of inflammatory response, apoptosis and autophagy pathway. This paper reviews the protective effect and mechanisms of the treatments of flavonoids on cardiovascular and cerebrovascular ischemic diseases by referring to relevant literatures. The purpose is to provide reference for future research and development of drugs for the treatments of cardiovascular and cerebrovascular diseases.
