Research progress on new dosage forms of progesterone and its preparation methods
10.16438/j.0513-4870.2021-0788
- VernacularTitle:黄体酮新剂型及其制备方法研究进展
- Author:
Yue WANG
1
;
Yi CHENG
2
;
Yuan-bing LIU
3
;
Jing-ru LI
2
;
Hui ZHANG
2
;
Ai-ping ZHENG
1
Author Information
1. School of Pharmacy, Xuzhou Medical University, Xuzhou 221000, China; Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
3. 73101 Unit of the Chinese People's Liberation Army, Xuzhou 221000, China
- Publication Type:Research Article
- Keywords:
progesterone;
clinical indication;
new dosage form;
new route of administration;
preparation method
- From:
Acta Pharmaceutica Sinica
2022;57(2):353-363
- CountryChina
- Language:Chinese
-
Abstract:
Progesterone is currently the first-line drug for the treatment and prevention of threatened abortion and habitual abortion. With the gradual liberalization of China's childbirth policy, the number of elderly parturients has increased significantly. As a result, the market demand for progesterone and the individual requirements have been continuously improved. Clinical studies have found that the indications of progesterone are not limited to gynecological diseases, but can also be used for the treatment of renal colic, traumatic brain injury and other diseases. Existing progesterone preparations include oral capsules, intramuscular injections, vaginal gels, etc., but they can no longer meet the current market situation and the increase of indications. Improving existing preparations, developing new preparations, and opening up new routes of administration have become one of the directions of progesterone drug research. This article will review the research progress of new dosage forms in existing administration, new routes of administration and related preparation methods of progesterone.
