Design and research progress of nano-drug delivery system based on mitochondria targeting
10.16438/j.0513-4870.2021-1321
- VernacularTitle:基于线粒体靶向纳米药物递送系统的设计及研究进展
- Author:
Bao-xin ZHENG
1
;
Chang-fen BI
2
;
Wen-bin HOU
2
;
Yi-liang LI
2
Author Information
1. Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
2. Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin 300192, China
- Publication Type:Research Article
- Keywords:
neoplasm;
mitochondria;
targeting;
rug delivery system;
chemotherapy;
nanotechnology;
therapy
- From:
Acta Pharmaceutica Sinica
2022;57(3):681-694
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria is involved in many important physiological activities such as energy supply, signal transduction, cell differentiation, etc., and plays an significant role in the occurrence and development of diseases. Using mitochondria as a target is a new strategy for cancer treatment. The use of nanotechnology to construct a mitochondrial targeted nano-drug delivery system can improve the solubility of traditional drugs, prolong the half-life of drugs in the body, increase the bioavailability and concentration of drugs at the tumor site, and reduce the toxic and side effects of drugs. It is expected to solve the resistance in the process of tumor treatment. This review focuses on the field of cancer treatment. Firstly, it introduces the mechanism of mitochondrial targeted nano-drug delivery system for cancer treatment. Secondly, it outlines the design ideas, classification and application research of mitochondrial targeted nano-drug delivery systems in the past five years. Finally, it expands the analysis of other studies that target mitochondria, such as bionic vectors, and presents its advantages and disadvantages, which provide a basis for in-depth research on drug delivery systems in the future.
