Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes.
10.1016/S1875-5364(21)60113-9
- Author:
Chang-Sheng SUN
1
;
Yu-Qin WANG
2
;
Zhong-Liang ZHANG
3
;
Yuligh LIOU
4
;
Hong-Hao ZHOU
5
Author Information
1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; China Zhejiang Bioasia Life Science Institute, Pinghu 314200, China.
2. China Zhejiang Bioasia Life Science Institute, Pinghu 314200, China. Electronic address: wyq@bioasia.com.cn.
3. China Zhejiang Bioasia Life Science Institute, Pinghu 314200, China.
4. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China.
5. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, China; National Clinical Research Center for Geriatric Disorders, Changsha 410008, China. Electronic address: 801004@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Adenosine;
Blood glucose and lipid;
HEA;
Isaria cicadae;
Quality control;
Type 2 diabetes model
- MeSH:
Animals;
Blood Glucose;
Cordyceps;
Diabetes Mellitus, Type 2/drug therapy*;
Metformin;
Quality Control;
Rats;
Rats, Wistar
- From:
Chinese Journal of Natural Medicines (English Ed.)
2021;19(12):921-929
- CountryChina
- Language:English
-
Abstract:
This work was aimed to establish a quality control method for evaluating the effects on glucose and lipids of the fruiting body of Isaria cicadae Miquel from strain Ic-17-7 (Ic-17-7fb) using a rat model of type 2 diabetes (T2DM). Random amplified polymorphic DNA, sequence-characterized amplified region, and high-performance liquid chromatography (HPLC) were used for the quality control of Ic-17-7fb. The pharmacological effects on streptozocin (STZ)-induced high fat diet (HFD)-fed Albino Wistar rats were evaluated. The rats underwent the following treatments: control, metformin, Ic-17-7fb (0.166 and 0.5 g·kg
