ERα promotes transcription of tumor suppressor gene

Bingjie WANG; Yinghui SHEN; Tianyu LIU; Li TAN

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ERα promotes transcription of tumor suppressor gene

Author: Bingjie WANG ¹ ; Yinghui SHEN ¹ ; Tianyu LIU ² ; Li TAN ³
Author Information

1. Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
2. Colorectal Cancer Center, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
3. Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. litan@fudan.edu.cn.
Publication Type:Journal Article
Keywords: Acetylation of histone 3 lysine 27 (H3K27ac); Apolipoprotein A-I (ApoA-I); Breast cancer; Estrogen receptor α (ERα); p300
From: Journal of Zhejiang University. Science. B 2021;22(12):1034-1044
CountryChina
Language:English
Abstract: Apolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport (RCT). Previous studies indicated a reduction of serum ApoA-I levels in various types of cancer, suggesting ApoA-I as a potential cancer biomarker. Herein, ectopically overexpressed ApoA-I in MDA-MB-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration. Subsequent studies on the mechanism of expression regulation revealed that estradiol (E2)/estrogen receptor α (ERα) signaling activates