Regulatory effects of miR-138 and RUNX3 on Th1/Th2 balance in peripheral blood of children with cough variant asthma.
10.7499/j.issn.1008-8830.2107029
- Author:
Zhi-Gang WANG
1
,
2
;
Gai-Qing SHEN
1
,
2
;
Yu-Huan HUANG
1
,
2
Author Information
1. Neonatal Intensive Care Unit, First People's Hospital of Nanyang City, Nanyang, Henan 473200, China (Email: wzg8107@
2. com).
- Publication Type:Journal Article
- Keywords:
Child;
Cough variant asthma;
MicroRNA-138;
Runt-related transcription factor 3;
Th1/Th2 balance
- MeSH:
Asthma;
Child;
Core Binding Factor Alpha 3 Subunit/genetics*;
Cough;
Humans;
Interleukin-13;
MicroRNAs/genetics*;
Th1 Cells;
Th1-Th2 Balance;
Th2 Cells
- From:
Chinese Journal of Contemporary Pediatrics
2021;23(10):1044-1049
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To study the expression levels of microRNA-138 (miR-138) and Runt-related transcription factor 3 (RUNX3) in peripheral blood of children with cough variant asthma (CVA) and their regulatory effects on Th1/Th2 balance.
METHODS:Sixty-five children with CVA (CVA group) and 30 healthy children (control group) were enrolled. Peripheral venous blood samples were collected for both groups, and CD4
RESULTS:Compared with the control group, the CVA group showed significantly decreased levels of IFN-γ and IL-2 from CD4
CONCLUSIONS:MiR-138 regulates Th1/Th2 balance by targeting RUNX3 in children with CVA, providing a new direction for the treatment of CVA.
