Depressive males have higher odds of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a retrospective cohort study based on propensity score matching.

Yang XIONG; Yang-Chang ZHANG; Tao JIN; Feng QIN; Jiu-Hong YUAN

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Depressive males have higher odds of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a retrospective cohort study based on propensity score matching.

Author: Yang XIONG ¹ ; Yang-Chang ZHANG ² ; Tao JIN ³ ; Feng QIN ¹ ; Jiu-Hong YUAN ¹
Author Information

1. Andrology Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.
2. Department of Epidemiology and Health Statistics, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China.
3. Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Publication Type:Journal Article
Keywords: aging males; benign prostatic hyperplasia; depression; lower urinary tract symptoms; propensity score matching
MeSH: Aged; China/epidemiology*; Cohort Studies; Depression/epidemiology*; Humans; Logistic Models; Longitudinal Studies; Lower Urinary Tract Symptoms/etiology*; Male; Middle Aged; Propensity Score; Prostatic Hyperplasia/epidemiology*; Retrospective Studies
From: Asian Journal of Andrology 2021;23(6):633-639
CountryChina
Language:English
Abstract: Lower urinary tract symptoms suggestive of benign prostate hyperplasia (LUTS/BPH) and depression are both increasing in Chinese aging males. However, the relationship still remains unknown. To explore their relationship, a retrospective cohort study based on propensity score matching (PSM) was conducted by analyzing the China Health and Retirement Longitudinal Study dataset. After data cleaning, a total of 5125 participants were enrolled and subjected to PSM; 1351 pairs were matched and followed for 2 years. Further logistic regression and restricted cubic spline (RCS) were performed to evaluate, model and visualize the relationship between depression and LUTS/BPH. Moreover, subgroup analyses and sensitivity analyses were adopted to verify the robustness of the conclusions. Before PSM, depressive patients showed higher odds of LUTS/BPH in all three models adjusting for different covariates (P < 0.001). After PSM, univariate logistic regression revealed that depressive patients had higher risks for LUTS/BPH than participants in the control group (odds ratio [OR] = 2.10, P < 0.001). The RCS results indicated a nonlinear (P < 0.05) and inverted U-shaped relationship between depression and LUTS/BPH. In the subgroup analyses, no increased risks were found among participants who were not married or cohabitating, received an education, had an abnormal body mass index (<18.5 kg m