The Mutated Gene Sequenced by NGS and the Correlation of Their Coexistent Mutual Exclusiveness in NPM1 Mutated Acute Myeloid Leukemia.
10.19746/j.cnki.issn.1009-2137.2021.06.007
- Author:
Li DAI
1
;
Zhi-Lin WANG
1
;
Guo-Qiang QIU
1
;
Yi-Cun WU
1
;
Xiu-Wen ZHANG
2
;
Shan-Shan XING
3
;
Biao WANG
4
,
5
Author Information
1. Department of Hematology, The Third Affiliated Hospital of Soochow University (Changzhou First People's Hospital), Changzhou 213000, Jiangsu Province, China.
2. Department of Hematology, Nanjing Medical University Affiliated Changzhou Second Hospital, Changzhou 213000, Jiangsu Province, China.
3. Department of Hematology, Zhejiang Hospital, Hangzhou 310013, Zhejiang Province, China.
4. Department of Hematology, The Third Affiliated Hospital of Soochow University (Changzhou First People's Hospital), Changzhou 213000, Jiangsu Province, China,E-mail: iamwangbiao@
5. com.
- Publication Type:Journal Article
- MeSH:
Base Sequence;
High-Throughput Nucleotide Sequencing;
Humans;
Leukemia, Myeloid, Acute/genetics*;
Mutation;
Nuclear Proteins/genetics*
- From:
Journal of Experimental Hematology
2021;29(6):1733-1740
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the clinicobiological heterogeneity of NPM1 mutated (NPM1
METHODS:The NGS data based on 112 genes related to blood disease in 238 newly diagnosed patients with NPM1
RESULTS:Among all the patients, at least one co-mutation was detected out. The median number per case of the mutated genes, including NPM1
CONCLUSION:Prognoses of AML involving less common NPM1 missense mutations should be stated on a case by case basis. The mutational landscape and co-occurrence and mutual exclusivity correlations of NPM1
