Clinical Characteristics and Prognosis Analysis of Pediatric Severe Aplastic Anemia.
10.19746/j.cnki.issn.1009-2137.2021.06.035
- Author:
Yu-Li CAI
1
;
Yang LAN
1
;
Mei-Hui YI
1
;
Jing FENG
1
;
Yuan-Yuan REN
1
;
Jing-Liao ZHANG
1
;
Shu-Chun WANG
1
;
Ye GUO
1
;
Yu-Mei CHEN
1
;
Xiao-Fan ZHU
2
Author Information
1. Department of Pediatric Hematology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
2. Department of Pediatric Hematology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.E-mail: xfzhu@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Anemia, Aplastic;
Cesarean Section;
Child;
Female;
Humans;
Immunosuppressive Agents;
Pregnancy;
Prognosis;
Retrospective Studies;
Treatment Outcome
- From:
Journal of Experimental Hematology
2021;29(6):1896-1902
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the clinical characteristics and factors affecting prognosis in children with severe aplastic anemia (SAA).
METHODS:Two hundred and five children with SAA treated in our department from January 2008 to April 2018 were selected, and the clinical characteristics and factors affecting prognosis were retrospectively analyzed.
RESULTS:Among 205 SAA children, the effective rate (CR+PR) at 3, 6 and 12 months after immunosuppressive therapy (IST) treatment was 50.9%, 59.0% and 73.9%, respectively, and 5-year overall survival rate was 93.1%±2.0%. Univariate analysis showed that 5-year overall survival rate of SAA children of spontaneous delivery was higher than that of cesarean section (P=0.039), while multivariate analysis showed that birth way had no significant influence on 5-year overall survival rate (P>0.05). The response rate at 3 months after IST of children with a recent history of decoration before SAA onset was higher than those without history of decoration (P<0.05).
CONCLUSION:Most of the SAA children can achieve high response rate and overall survival rate. Patients with recent history of home/school decoration may be the factor affecting hematological response after 3 months of IST, but have no influence on long-term overall survival.
