Correlation of B-type Natriuretic Peptide Level with Hemodynamic Parameters and Inflammatory Cytokines in Patients with Gram-negative Sepsis.
10.3881/j.issn.1000-503X.14022
- Author:
Hao HUANG
1
;
Xiang-Ping CHEN
1
;
Cheng-Jin LI
1
;
Feng-Zhu CHEN
1
;
Li-Wei LIN
1
;
Jin-Yan ZHANG
1
;
Zhen-Zhen TENG
1
;
Bai-Ying ZHAO
1
Author Information
1. Department of Intensive Care Unit,Fujian Provincial Hospital North Branch, Fujian Provincial Geriatric Hospital,Fuzhou 350003,China.
- Publication Type:Journal Article
- Keywords:
B-type natriuretic peptide;
Gram-negative bacteria;
cardiac function;
inflammatory cytokines;
sepsis
- MeSH:
Cytokines;
Gram-Negative Bacterial Infections;
Hemodynamics;
Humans;
Natriuretic Peptide, Brain;
Prognosis;
Prospective Studies;
Sepsis;
Stroke Volume;
Ventricular Function, Left
- From:
Acta Academiae Medicinae Sinicae
2021;43(6):879-885
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of B-type natriuretic peptide(BNP)level with hemodynamic parameters and inflammatory cytokines in patients with Gram-negative sepsis,and further determine the main factors for the significant increase of BNP level. Methods The prospective study method was applied,and septic patients infected with Gram-negative bacteria from May 2017 to October 2019 were enrolled.The patients were divided into the BNP<2400 ng/L group and the BNP≥2400 ng/L group by taking the average value of BNP as the dividing point.The independent predictors of BNP≥2400 ng/L were analyzed by Logistic regression.Pearson correlation analysis was used to analyze the correlation between BNP and various indicators. Results A total of 106 patients with Gram-negative sepsis were included,among which 60 cases present with higher serum BNP levels than the average of(2398.45 ± 421.45)ng/L.Thus BNP≥2400 ng/L was considered as a significantly increased BNP level.Multiple logistic regression analysis showed that cardiac index(CI)[odds ratio (
