Evaluation of the Efficacy of Cyclosporin A Combined with Recombined Human Erythropoietin in the Treatment of Patients with Chronic Aplastic Anemia.
10.3881/j.issn.1000-503X.13201
- Author:
Wan-Shu CHEN
1
;
Meng-Lu ZHANG
1
;
Bing HAN
1
Author Information
1. Department of Hematology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
- Publication Type:Journal Article
- Keywords:
chronic aplastic anemia;
cyclosporin A;
efficacy;
recombined human erythropoietin;
side effects
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Anemia, Aplastic/drug therapy*;
Cyclosporine/therapeutic use*;
Erythropoietin/therapeutic use*;
Female;
Humans;
Male;
Middle Aged;
Recombinant Proteins;
Remission Induction;
Retrospective Studies;
Young Adult
- From:
Acta Academiae Medicinae Sinicae
2021;43(5):736-742
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of cyclosporin A(CsA)and CsA combined with recombined human erythropoietin(rhEPO)in the treatment of patients with chronic aplastic anemia(CAA).Methods Data of 79 patients with CAA treated at Department of Hematology,PUMC Hospital between January 2016 and June 2018 were collected for retrospective analysis.Forty-five patients were treated with CsA+rhEPO,and the other 34 patients with CsA alone.All the enrolled patients were treated for at least 1.5-2.0 years and followed for at least 1.0 year.The efficacy,side effects,long-term outcomes were compared between the two groups,and factors that may influence the efficacy were analyzed.Results The patients treated with CsA+rhEPO included 14 males and 31 females,with a median age of 43(19,73)years old.The median treatment duration of CsA and rhEPO was 26(12,38)and 4(3,6)months,respectively,and the median followed-up time was 24(12,42)months.The patients treated with CsA alone included 16 males and 18 females,with a median age of 36(16,85)years old.The median CsA treatment duration was 24(12,40)months and the median follow-up time was 25(12,40)months.There was no statistical difference in baseline characteristics between the two groups(all
