Application of bioisostere-bicyclo [1.1.1] pentane (BCP) in drug design
10.11665/j.issn.1000-5048.20220101
- VernacularTitle:生物电子等排体双环[1.1.1]戊烷(BCP)在药物设计中的应用
- Author:
Yu HUANG
1
;
Yinsheng ZHANG
Author Information
1. 正大天晴药业集团股份有限公司，江苏省抗病毒靶向药物研究重点实验室
- Publication Type:Journal Article
- Keywords:
bicyclo[1.1.1] pentane;
bioisostere;
drug design
- From:
Journal of China Pharmaceutical University
2022;53(1):1-9
- CountryChina
- Language:Chinese
-
Abstract:
With the development of medicinal and organic chemistry, more and more classical and non-classical bioisosteres are used in the design of novel drugs.Bicyclo[1.1.1] pentane (BCP), as a bioisostere of benzene, t-butyl and alkyne moieties,has recently received extensive attention from medicinal and organic chemists.This paper briefly reviews its application in drug design to provide reference for drug discovery researchers.
