Adverse drug reactions induced by hydroxychloroquine in the treatment of oral lichen planus: a report of 13 cases
10.12016/j.issn.2096-1456.2022.05.007
- Author:
LIN Yao
1
;
HUANG Jing
1
;
XUE Xiaojuan
1
;
ZHANG Huan
1
;
FENG Bin
1
Author Information
1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Pharmacy, School of Stomatology, the Fourth Military Medical University
- Publication Type:Journal Article
- Keywords:
hydroxychloroquine;
oral mucosal disease;
adverse-drug reaction;
optic neurotoxicity;
vision screening;
cardiotoxicity;
medication safety;
package inserts of drug
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2022;30(5):350-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective : To analyze the adverse drug reaction（ADR） reports of hydroxychloroquine for clinical medication safety.
Methods:The ADR reports of hydroxychloroquine between May 2019 and May 2021 were analyzed. Age, reasons for drug use, time of ADR, combined drug use, and ADR outcomes were statistically analyzed.
Results: No severe ADR was reported. Patients over 60 years old accounted for 53.85% of the total cases, and the time of ADR appearance was significantly earlier among those under 60 years old. A total of 61.54% of ADRs were involved in multiple organs, and optic neurotoxicity was reported in 46.15% of cases.
Conclusion: In the treatment of oral lichen planus with hydroxychloroquine, adverse drug reactions should be monitored, and increased attention should be given to patients over 60 years old to ensure the safety of this medication.
- Full text:硫酸羟氯喹治疗口腔扁平苔藓13例不良反应报告.pdf
