Characteristics and intervention strategies of chronic hepatitis B complicated with nonalcoholic fatty liver disease
10.3969/j.issn.1006-2483.2022.01.034
- VernacularTitle:慢性乙型肝炎合并非酒精性脂肪肝的临床特征分析
- Author:
Xiaohong PEI
1
;
Xiaoxuan ZHU
1
;
Tingting WANG
1
;
Qing ZHU
2
Author Information
1. Department of Gastroenterology, Suzhou Medical District, Joint Logistics Support Force 904th Hospital ; Suzhou, Jiangsu 215000 , China
2. Department of Gastroenterology, Eastern Theater Air Force Hospital of the Chinese People's Liberation Army , Nanjing 210002 , China
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Nonalcoholic fatty liver disease;
Intervention strategy
- From:
Journal of Public Health and Preventive Medicine
2022;33(1):154-157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of chronic hepatitis B (CHB) complicated with non-alcoholic fatty liver disease (NAFLD), and to provide countermeasures for the prevention of NAFLD. Methods A total of 348 patients with CHB admitted to our hospital from June 2018 to June 2021 were randomly selected and divided into experimental group (CHB combined with NAFLD, n=195) and control group (CHB, n=153) according to whether they had NAFLD or not. Basic data such as age, sex, BMI (kg/m2), history of diabetes, history of hypertension, and history of alcohol consumption were collected. Serum indexes such as liver function (AST, ALT, GGT, ALP, ALB), blood lipid (TG, ldl-c), fasting blood glucose (FBG) and virological indexes such as hepatitis B virus (HBV DNA) were collected. Results A total of 348 CHB patients were included in the study, including 195 (56.03%) patients with NAFLD. The high NAFLD incidence age was between 30 and 45 years old (163 cases, 46.84%). The incidence of NAFLD in male (131 cases, 70.81%) was significantly higher than that in female (64 cases, 39.26%) (χ2=35.005, P<0.05). The incidence of NAFLD in male patients was significantly higher than that in female patients at age <30 and 30~45 (χ2=10.625, χ2=20.238, P<0.05). There was no significant difference in the incidence rate of NAFLD between men and women at age >45 years (χ2=2.005, P>0.05). There were no significant differences in the history of hypertension, ALT and ALP between the two groups (P>0.05). The differences in age, sex, BMI, history of diabetes, history of alcohol consumption, AST, TG, TG, FBG and FBG between the two groups were statistically different (P<0.05). Logistic regression analysis showed that increased BMI, AST, FBG and LDL were independent risk factors for NAFLD in CHB patients (P<0.05). Conclusions CHB with NAFLD often has glucolipid metabolic disorder, which is related to increased body mass index and AST. It is suggested that we should strengthen the health management of patients with high blood pressure, diabetes, overweight, and obesity, guide patient to balance their diet, adjust their diet structure, control their body weight and glycolipid abnormalities, adjust body fat, reduce blood pressure by drugs, and control blood sugar in a timely manner, and maintain a healthy lifestyle.
