Predominant Myofibrillar Pathology with Preserved Sarcolemmal Aquaporin 4 Immunoreactivity in a Patient with Neuromyelitis Optica-Associated HyperCKemia
10.7180/kmj.2021.36.2.206
- Author:
So-Young HUH
1
;
Jin-Hong SHIN
;
Yeong-Eun PARK
;
Ho Jin KIM
;
Dae-Seong KIM
Author Information
1. Department of Neurology, Kosin University College of Medicine, Busan, Republic of Korea
- Publication Type:Case Reports
- From:Kosin Medical Journal
2021;36(2):206-210
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 49-year-old man developed recurrent myalgia and hyperCKemia during acute attacks of neuromyelitis optica. Muscle biopsy was performed, and the pathological findings were analyzed. Predominant myofibrillar pathology was observed, which constitutes a unique finding that has not been reported before. This case result shows that neuromyelitis optica-associated hyperCKemia can produce variable pathologic phenotypes. Further studies are needed to elucidate the relationship between myofibril destruction and aquaporin 4 autoimmunity.
