A Case of POEMS Syndrome Previously Diagnosed with Extramedullary Plasmacytoma
10.46518/kjnmd.2021.13.2.59
- Author:
Hyunkee KIM
1
;
Sanggon LEE
Author Information
1. Department of Neurology, College of Medicine, Hanyang University, Seoul, Korea
- Publication Type:Case Report
- From:
Korean Journal of Neuromuscular Disorders
2021;13(2):59-63
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome is a rare multisystem disorder associated with osteosclerotic myeloma. It is characterized by peripheral polyneuropathy, presence of monoclonal plasma cell proliferative disorder, and one or more of the following features – sclerotic bone lesions, Castleman disease, elevated levels of vascular endothelial growth factor, organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema, and thrombocytosis. Extramedullary plasmacytoma (EMP) is a rare plasma cell neoplasm that arises in isolated tissues without bone marrow involvement or systemic characteristics of multiple myeloma. Herein, we report a male patient who was previously diagnosed with EMP and later developed POEMS.
