A Case of Sorafenib-induced DRESS Syndrome in Hepatocelluar Carcinoma.
10.4166/kjg.2016.67.6.337
- Author:
Dong Kyun KIM
1
;
Sung Woo LEE
;
Hwa Seong NAM
;
Dong Sub JEON
;
Na Rae PARK
;
Young Hee NAM
;
Soo Keol LEE
;
Yang Hyun BAEK
;
Sang Young HAN
;
Sung Wook LEE
Author Information
1. Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. sunglee@dau.ac.kr
- Publication Type:Case Report
- Keywords:
DRESS syndrome;
Sorafenib;
Hepatocellular carcinoma
- MeSH:
Aged;
Carcinoma, Hepatocellular;
Drug Hypersensitivity Syndrome*;
Eosinophilia;
Fever;
Humans;
Liver Cirrhosis, Alcoholic;
Skin
- From:The Korean Journal of Gastroenterology
2016;67(6):337-340
- CountryRepublic of Korea
- Language:English
-
Abstract:
Sorafenib is currently the only targeted therapy available for advanced stage hepatocellular carcinoma (HCC). Cutaneous adverse events associated with sorafenib treatment include hand-foot skin reaction, but there has been no report of drug reaction (or rash) with eosinophilia and systemic symptoms (DRESS) syndrome. Here, we report a case of 72-year-old man with HCC and alcoholic liver cirrhosis who developed skin eruptions, fever, eosinophilia, and deteriorated hepatic and renal function under sorafenib treatment. He has since successfully recovered with conservative care.
